Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
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Choline Intake and Risk of Lethal Prostate Cancer Incidence and Survival
Richman, E.L., Kenfield, S.A., Stampfer, M.J., Giovannucci, E.L., Zeisel, S.H., Willett, W.C., Chan, J.M. (2012) Choline intake and risk of lethal prostate cancer: incidence and survival. American Journal of Clinical Nutrition. 96(4): 855 – 863. PMID: 22952174.
p38 Mitogen-activated Protein Kinase (MAPK) PromotesCholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophag
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Teng, Y-W, Ellis, J.M., Coleman, R.A., Zeisel, S.H. (2012) Mouse Betaine-Homocysteine S-Methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue. e. Journal of Biological Chemistry. 287(20): 16187 – 98. PMID: 22362777.
Homocysteinemia in Mice with Genetic Betaine Homocysteine S-Metyltransferase Deficiency is Independent of Dietary Folate Intake
Teng, Y-W, Cerdena, I., Zeisel, S.H. (2012) Homocysteinemia in Mice with Genetic Betaine Homocysteine S-Methyltransferase Deficiency Is Independent of Dietary Folate Intake. The Journal of Nutrition. Doi:10.3945/jn.112.166835. PMID: 23014492.
The Epigenetic Effects of a High Prenatal Folate Intake in Male Mouse Fetuses Exposed in Utero to Arsenic
Tsang, V., Fry,R., Niculescu, M., Saunders, J., Paul, D., Zeisel, S.H., Waalkes, M., Styblo, M., Drobna, Z. (2012) The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic toxicology and applied pharmacology. Toxicology and Applied Pharmacology. doi: 10.1016/j.taap.2012.08.22.