Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Diet Gene Interactions Underlie Metabolic Individuality and Influence Brain Development Implications for Clinical Practice
Zeisel, S.H. (2012) Diet-Gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice. Annuals of Nutrition and Metabolism. 60: 19 – 25.
Metabolic Crosstalk between Choline 1 Carbon Metabolism and Energy Homeostasis
Zeisel, S.H. (2012) Metabolic crosstalk between choline/1-carbon metabolism and energy homeostatis. Clinical Chemistry and Laboratory Medicine. doi: 10.1515/cclm-2012-0518. PMID: 23072856.
Choline
Zeisel, S.H., Corbin, K. (2012) Choline. In 10th Edition of Present Knowledge of Nutrition, jointly edited by J.W. Erdman, I.A. MacDonald and S.H. Zeisel,Wiley-Blackwell, Hoboken, NJ. 659 – 681.
Highlights of the 2012 Research Workshop: Using Nutrigenomics and Metabolomics in Clinical Nutrition Research
Zeisel, S.H., Waterland, R.A., Ordovas, J.M., Muoio, D., Jia, W., Fodor, A. (2012) Highlights of the 2012 Research Workshop: Using Nutrigenomics and Metabolomics in Clinical Nutrition Research. Journal of Parenteral and Enteral Nutrition. doi: 10.1177/0148607112462401.
Choline Modern Nutrition in Health and Disease, 11th Ed.
Zeisel, S.H. (2012) Choline. In Modern Nutrition in Health and Disease, 11th Edition. Edited by C. Ross, B. Caballero, R. Cousins, K. Tucker, T. Ziegler, Lippincott Williams & Wilkins, Monkton, VT 416 – 426.
A 45-Minute Vigorous Exercise Bout Increases Metabolic Rate for 14 Hours
Knab, AM, Shanely, RA, Corbin, KD, Jin, F, Nieman, DC. (2011) A 45-min Vigorous Exercise Bout Increases Metabolic Rate for 14 hours. Med Sci Sports Exerc. 43(9):1643-1648. PMID:2131136