Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Choline Dehydrogenase Polymorphism RS12676 is a Functional Variation and is Associated with Changes in Human Sperm Cell Function
Johnson, A.R., Lao, S., Wang, T., Galanko, J.A., Zeisel, S.H. (2012) Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function. PLoS ONE. 7(4): e36047. PMID: 22558321.
Perinatal Epigenetic Determinants of Cognitive and Metabolic Disorders
Lupu DS and Niculescu MD (2012) Perinatal Epigenetic Determinants of Cognitive and Metabolic Disorders. Aging and Disease 3
Maternal-linolenicacid availability during gestation and lactation alters the postnatal hippocampal Development in the Mouse Offspring
Niculescu MD, Lupu, DS and Craciunescu CN (2012) Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. The FASEB Journal 27
Choline Intake and Risk of Lethal Prostate Cancer Incidence and Survival
Richman, E.L., Kenfield, S.A., Stampfer, M.J., Giovannucci, E.L., Zeisel, S.H., Willett, W.C., Chan, J.M. (2012) Choline intake and risk of lethal prostate cancer: incidence and survival. American Journal of Clinical Nutrition. 96(4): 855 – 863. PMID: 22952174.
p38 Mitogen-activated Protein Kinase (MAPK) PromotesCholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophag
Shuang Mei, Haihua Gu, Adam Ward, Xuefeng Yang, Huailan Guo, Ka He, Zhenqi Liu, and Wenhong Cao (2012) p38 Mitogen-activated Protein Kinase (MAPK) Promotes Cholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophagy THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 15, pp. 11761–11768
Mouse Betaine-Homocysteine S-Methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue
Teng, Y-W, Ellis, J.M., Coleman, R.A., Zeisel, S.H. (2012) Mouse Betaine-Homocysteine S-Methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue. e. Journal of Biological Chemistry. 287(20): 16187 – 98. PMID: 22362777.