Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

Chinese herb may be a natural method of treating diabetes

May 31, 2019 – The traditional Chinese herb Lycii Cortex (LyC), with its powerful compound kukoamine B, could be an effective nutraceutical choice for lowering blood glucose when used alone or in combination with low doses of first-line diabetes medications.

The DNA Diet: How knowing your genes can help you fit into your jeans

May 28, 2019 – Most people have this basic understanding of genetics: You inherit genes from your parents, and their DNA combines to create your unique genetic makeup. This can include more obvious traits such as eye color and height but also more complex traits that may involve multiple genes, such as risk of diseases including diabetes, heart disease, obesity and cancer, as well as all aspects of metabolism.

Zeisel receives AICR’s Distinguished Service Award

May 20, 2019 – Steven Zeisel, MD, PhD, professor in the Department of Nutrition at the UNC Gillings School of Global Public Health and director of the UNC Nutrition Research Institute in Kannapolis, N.C., was awarded the American Institute for Cancer Research’s (AICR) Distinguished Service Award at the institute’s annual meeting May 16, 2019.

Sign-up for an NRI Summer Tour

May 20, 2019 – See where and learn how scientific discovery takes place by touring two facilities on the NC Research Campus in Kannapolis: the UNC Nutrition Research Institute and the NCSU Plants for Human Health Institute. Register today!

Studies Explore Mechanisms Behind Obesity-Cancer Link

May 20, 2019 – Research findings presented at the American Association for Cancer Research Annual Meeting 2019 explore possible reasons for obesity-related resistance to breast cancer treatment and possible strategies to overcome obesity-related immune suppression in cancer.

Nutrition Decisions in a Conflicting World: Eggs-actly the Issue

April 18, 2019 – How are we expected to make healthy choices about food when the headlines are so confusing? We all suffer whiplash when we read butter is bad, then butter is good; when red meat is bad, then red meat is good; when red wine is good, and then it is bad….so, what is the headline du jour?