Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

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November Faculty Focus: Steven H. Zeisel, PhD

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November 13, 2018 – From his lab in a textile mill-turned-food research center, a UNC scientist has brought an important nutrient to the world’s attention. Dr. Steven Zeisel wants to make sure you’re getting enough choline. In a state-of-the-art laboratory on the North Carolina Research Campus, in the unlikeliest of places in a former textile mill town, Zeisel is overseeing scientific experiments about a nutrient that could change the way we eat.

AFL@JWU Recipes – October 17, 2018

AFL@JWU Recipes – October 17, 2018

October 17, 2018 – Chef Megan Lambert, MS, RD, Senior Instructor in College of Culinary Arts at Johnson & Wales University, Charlotte, prepared healthy, delightful recipes with “Fun(ctional) Fall Flavors while Steph Saullo, MS, RD of the UNC Nutrition Research Institute, shared nutrition information on each recipe. The recipes from the October 17, 2018 Appetite For Life @ Johnson & Wales University program are available here for your cooking enjoyment!

AFL Program Summaries September 2018 – May 2019

Appetite For Life – Wednesday, September 19, with Delisha Stewart, PhD, Assistant Professor of Nutrition, UNC NRI: “Race, Ethnicity, and Health Disparities” Scientists at the Nutrition Research Institute are studying the role of genetics in health and wellness....