Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Why a Fly?
January 29, 2018 – The genome of a fruit fly is strikingly similar to that of a human — so much so that scientists have been studying these tiny insects for over 100 years, in search of treatments for diseases like spinal muscular atrophy and neurological disorders. UNC geneticist and director of the Integrative Program for Biological and Genome Sciences Bob Duronio, PhD is one of those scientists. “It begins with curiosity. Curiosity about a process. And then a question about that process. And then a hypothesis that will lead to an experiment that will provide results and data to interpret. What I love about this process is that my hypotheses are often wrong. And that’s really exciting — because no human being is smart enough to understand biology at a level of molecular detail where their hypotheses are always right.”
Whole Foods and Nutrient Synergy
January 29, 2018 – Have you ever wondered why we eat certain foods together? What is it about pork that demands applesauce? Wouldn’t a lovely piece of hard cheese go well with that glass of red wine? Is beef and broccoli just a dish or might there be a benefit to eating those together? It is difficult to trace how these traditional pairings got started. Apples with pork dates back to the time of Christ when an Ancient Roman named Apicius wrote down a recipe, but where did he get the idea? We find a clue in the story of why we eat mint with lamb. In an attempt to decrease the consumption of lamb and thereby increase wool exports, Queen Elizabeth I declared it unlawful to eat lamb without mint sauce, presumably because people disliked the taste of mint sauce (basically mint and vinegar). As it turned out, mint sauce was a great compliment to lamb. So, yes. Your first instinct was correct – we eat certain foods together because they taste good together!
January 2018
Quinoa Compounds Slow Aging, Improve Metabolic Health in Animal Study December 27, 2017 – In a collaboration between Rutgers University and the N.C. State University Plants for Human Health Institute (PHHI) at the NC Research Campus (NCRC), scientists used an animal...
Caramelized Pear, Roasted Tomato and Lentil Salad
December 29, 2017 – This fresh New Year salad combines the natural sweetness of caramelized pear and roasted tomato, with earthy lentils and tender butter lettuce. Finished with lemon zest, olive oil and balsamic vinegar, this elegant salad lends starts the New Year off on a healthy note.
Quinoa Compounds Slow Aging, Improve Metabolic Health in Animal Study
December 27, 2017 – In a collaboration between Rutgers University and the N.C. State University Plants for Human Health Institute (PHHI) at the NC Research Campus (NCRC), scientists used an animal model to show for the first time that quinoa phytochemicals, such as ecdysteroids, may slow the effects of aging and improve metabolic health. Their study was published in the October 2017 edition of the Journal of Functional Foods.
Quinoa Breakfast Bars with Blueberries
December 29, 2017 – A great recipe to get your day started!