Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
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May 2017
Shedding Light on Genetic Associations with Cancer Many of the genes we study at the NRI are involved in nutrient metabolism. One of the ways we can learn about what a gene does is to delete it in an animal model and then see how the gene-deleted animals differ from...
Shedding Light on Genetic Associations with Liver Cancer
May 1, 2017 • Many of the genes we study at the NRI are involved in nutrient metabolism. One of the ways we can learn about what a gene does is to delete it in an animal model and then see how the gene-deleted animals differ from normal animals. By observing how disruption of a gene affects an animal’s growth, development, and health, we can develop insights into […]
Whole Grains Prevent Chronic Lifestyle Disease in More Ways Than One
May 1, 2017 • Whole grains have more health benefits to offer other than those from consuming fiber. These plant foods are also unique and rich sources of phytochemicals, bioactive compounds exclusively produced by plants that lower the risk of chronic disease. Whole grains contain dietary fiber, vitamins and minerals, and phytochemicals, but […]