Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

Healthy Cooking for the Holidays: Recipes

November 16, 2016 • Appetite for Life is a series of community programs produced by the NRI brings the latest nutrition science research down to earth in educational and interactive lectures, demonstrations and events. NRI and JWU collaborated to bring the Cooking for Nourishment Demo, Healthy Cooking for the Holidays. See the recipes here.

Mom’s Diet Can Affect Development of Next Two Generations

November 17, 2016 • Nutritional deficiencies during pregnancy can have lasting effects across generations that impact development not only of children, but also of grandchildren. These heritable effects are linked to epigenetic changes that affect gene expression but not DNA sequence. At the NRI, we seek to understand how nutrition affects health and why different people respond differently to the same nutrients.

Nutrition Research Institute Shows Choline is Essential to a Normal Diet

November 1, 2016 • Though it’s present in a variety of foods and an essential part of a person’s diet, many people may not have heard of the nutrient choline.
Researchers from the University of North Carolina at Chapel Hill’s Nutrition Research Institute, located at the NC Research Campus in Kannapolis, have studied the impact that diets lacking in choline could have on everything from liver and muscle tissue to brain development.

November 2015

November 1, 2015 • In this edition of our monthly e-news learn why researchers say no drinking when pregnant, is life expectancy a good measure of health and congratulate Dr. Hursting on his latest award.

November 2016

Do Eggs Cause Heart Disease? Several recent studies linked increased levels of a metabolic product of dietary choline with higher risk of cardiovascular disease (CVD) (Wang  et al., 2011; Tang  et al., 2013) through a mechanism that involved gut microbiota-produced...

Do Eggs Cause Heart Disease?

October 25, 2016 • Several recent studies linked increased levels of a metabolic product of dietary choline with higher risk of cardiovascular disease (CVD) (Wang et al., 2011; Tang et al., 2013) through a mechanism that involved gut microbiota-produced trimethylamine oxide (TMAO). These studies have sparked considerable scientific (and non-scientific) discussion, with health advice from some groups suggesting avoidance of meat and eggs (significant sources of choline) and from others suggesting that the findings have been vastly overinterpreted.