Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Dr. Zeisel discusses nutrition at November Chamber of Commerce breakfast
November 20, 2017 – Recommending proper nutrition can be difficult because not all people are the same, according to Dr. Steven Zeisel of the Kannapolis-based North Carolina Research Campus. “And that’s why nutrition research has been so frustrating. You read in Newsweek one week that you should drink less coffee and, the next week, you should drink more,” Zeisel said. He said much of the “fuzziness” in nutrition research has come from scientists not knowing why one person responds to a certain nutrient while others do not. That’s why his institute at the Research Campus is trying to be the leading group of faculty asking — and answering — that question.
November 2017
What's Essential for the Prenatal Brain? October 25, 2017 – An interview with Steven H. Zeisel, MD, PhD, Kenan Distinguished University Professor of Nutrition and Pediatrics, and Director, UNC Nutrition Research Institute, Kannapolis, NC. SZ: “In science, 10 percent...
Nutrition Training for Young Doctors Lacks Bite
October 25, 2017 – Most US medical schools do not require medical students to learn basic nutrition theory, even though poor diet is the leading preventable risk factor for disability or early death in the United States. “It takes at least 25-30 hours of medical school instruction to achieve just basic nutrition competencies,”
What’s Essential for the Prenatal Brain?
October 25, 2017 – An interview with Steven H. Zeisel, MD, PhD, Kenan Distinguished University Professor of Nutrition and Pediatrics, and Director, UNC Nutrition Research Institute, Kannapolis, NC.
“In science, 10 percent of successful scientific discovery is the result of skill and hard work – but 90 percent comes from asking the right question. During my graduate training, I was very lucky to ask the right question. I wondered where the choline in acetylcholine comes from. Acetylcholine is an organic chemical that serves as a neurotransmitter – it’s released by nerve cells and sends signals to other cells, such as in muscles. At the time, all the textbooks stated that people could make their own supply of this nutrient in the liver and did not need to obtain it through food. I knew that this was not true for rats, mice and dogs, and I doubted it was true for people.
Nutrition Notes from AFL@JWU – October 17
October 17, 2017 – The science on food and nutrients and their relationship to disease is complex, especially related to cancer. Cancer in and of itself is a complex disease that is not fully understood. As consumers, we often find ourselves inundated with the latest nutrition “story of the day” and often that story conflicts with a headline we may have seen only a week before. This simply makes trying to differentiate science and nutrition guidance more confusing. Scientists at the UNC Nutrition Research Institute (NRI) are working very hard to understand the intricacies of diet, nutrients, and their relationship to cancer prevention and progression.
AFL@JWU Recipes – October 17
October 17, 2017 – Chef Megan Lambert, MS, RD, Senior Instructor in College of Culinary Arts atJohnson & Wales University, Charlotte, prepared healthy, delightful recipes while Steph Saullo, RD of the UNC Nutrition Research Institute, shared nutrition information on each recipe. The recipes from the October 17 Appetite For Life are available here for your cooking enjoyment!