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Our research not only influences the scientific community, but the general public as well. We strive to share our discoveries with everyone. Read some of our latest articles on what is happening at the Nutrition Research Institute.
Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation
Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation.
Oleinik NV, Helke KL, Kistner-Griffin E, Krupenko NI, Krupenko SA.
J Biol Chem. 2014 Sep 19;289(38):26383-94. doi: 10.1074/jbc.M114.569657. Epub 2014 Aug 1.
PMID: 25086046
Molecular mechanisms underlying the potentially adverse effects of folate
Molecular mechanisms underlying the potentially adverse effects of folate.
Strickland KC, Krupenko NI, Krupenko SA.
Clin Chem Lab Med. 2013 Mar 1;51(3):607-16. doi: 10.1515/cclm-2012-0561. Review.
PMID: 23241610
ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A
ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A.
Oleinik NV, Krupenko NI, Krupenko SA.
Oncogene. 2010 Nov 25;29(47):6233-44. doi: 10.1038/onc.2010.356. Epub 2010 Aug 23.
PMID: 20729910
Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes
Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes.
Strickland KC, Holmes RS, Oleinik NV, Krupenko NI, Krupenko SA.
Chem Biol Interact. 2011 May 30;191(1-3):122-8. doi: 10.1016/j.cbi.2010.12.025. Epub 2011 Jan 6.
PMID: 21215736
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.
Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA.
J Biol Chem. 2010 Jul 23;285(30):23056-63. doi: 10.1074/jbc.M110.128843. Epub 2010 May 24.
PMID: 20498374
Acyl carrier protein-specific 4′-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase
Acyl carrier protein-specific 4′-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.
Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA.
J Biol Chem. 2010 Jan 15;285(3):1627-33. doi: 10.1074/jbc.M109.080556. Epub 2009 Nov 20.
PMID: 19933275
Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6
Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6.
Hoeferlin LA, Fekry B, Ogretmen B, Krupenko SA, Krupenko NI.
J Biol Chem. 2013 May 3;288(18):12880-90. doi: 10.1074/jbc.M113.461798. Epub 2013 Mar 21.
PMID: 23519469
January 2015
Clinical Studies at the Nutrition Research Institute The Nutrition Research Institute is committed to conducting innovative, basic and translational science to support the understanding of individualized nutrition. These advances in science promote the prevention and...
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans.
Kohlmeier M, da Costa KA, Fischer LM, Zeisel SH.
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16025-30. Epub 2005 Oct 18.
PMID: 16236726