News
Our research not only influences the scientific community, but the general public as well. We strive to share our discoveries with everyone. Read some of our latest articles on what is happening at the Nutrition Research Institute.
Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.
Choline: The Underconsumed and Underappreciated Essential Nutrient.
Choline.
Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.
Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.
Genetic Signatures in Choline and 1-Carbon Metabolism
Corbin, K. D., Abdelmalek, M. F., Spencer, M. D., da Costa, K. A., Galanko, J. A., Sha, W., Suzuki, A., Guy, C. D., Cardona, D. M., Torquati, A., Diehl, A. M., and Zeisel, S. H. (2013) Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB J 27, 1674-1689
Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.
Dietary Choline Requirements of Women Effects of Estrogen and Genetic Variation
Fischer, L.M., da Costa, K-A, Kwock, L., Galanko, J., Zeisel, S.H. (2010) Dietary choline requirements of women: effects of estrogen and genetic variation. American Journal of Clinical Nutrition. 92(5):1113-19. PMCID: PMC2954445.