Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis
“Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis”. Tang X, Keenan MM, Wu J, Lin CA, Dubois L, Thompson JW, Freedland SJ, Murphy SK, Chi JT (2015). PLoS Genet. 11(4).
Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
“Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress”. LaMonte GM, Tang X, Chen LY, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB and Chi JT (2013). Cancer & Metabolism, 1(1): 23.
A joint analysis of metabolomics and genetics of breast cancer
“A joint analysis of metabolomics and genetics of breast cancer”. Tang X, Lin CC, Spasojevic I, Iversen ES, Chi JT, Marks JR (2014). Breast Cancer Res. 16(4): 415.
A high-throughput screening method for small molecule inhibitors of the aberrant mutant SOD1 and Dynein interaction
“A high-throughput screening method for small molecule inhibitors of the aberrant mutant SOD1 and Dynein interaction”. Tang X, Seyb KI, Huang M, Schuman ER, Shi P, Zhu Z, Glicksman MA (2012). Journal of Biomolecular Screen (3): 314-26.
Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs
“Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs”. Tang X, Joseph Lucas JE, Ling-Yu J. Chen JL, LaMonte G, Wu J, Wang MC, Costantinos Koumenis Chi JT (2012). Cancer Research, 72(2): 491-502.
December 2014
Appetite for Life Public Programing Mark Your Calendar The Nutrition Research Institute's popular series of public programs, called Appetite for Life, resumes this January for a five-month run. Once each month, January through May, distinguished science researchers...