Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
Do you have the cure for the common cold?
February 26, 2018 – Everyone gets the common cold; hence, its name. Why isn’t there a cure or preventative vaccine? Actually there is, and you have it already – an active lifestyle including regular physical activity. David Nieman, DrPH, FACSM, the director of the Appalachian State University Human Performance Laboratory at the NC Research Campus, explains.
Choline Biomarker Study Wins Federal Support
February 7, 2018 – UNC Nutrition Research Institute director Steven H. Zeisel, MD, PhD has been awarded a four-year, $2.6 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), one of the National Institutes of Health, to develop and validate a panel of laboratory tests that can assess choline status in humans.
Study of first-graders shows fetal alcohol spectrum disorders prevalent in US communities
February 6, 2018 – Philip A. May, PhD, research professor at the UNC Nutrition Research Institute, led NIH-funded research that examined over 6,000 children to determine prevalence of FASD ranged from 1.1 to 5 percent.
A new study of more than 6,000 first-graders across four U.S. communities has found that a significant number of the children examined, as many as 5 percent in one community sample, may have fetal alcohol spectrum disorders (FASD). Funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, the new findings may represent more accurate prevalence estimates of FASD among general U.S. communities than prior research. Previous FASD estimates were based on smaller study populations and do not reflect the overall U.S. population.
February 2018
Whole Foods and Nutrient Synergy January 29, 2018 – Have you ever wondered why we eat certain foods together? What is it about pork that demands applesauce? Wouldn’t a lovely piece of hard cheese go well with that glass of red wine? Is beef and broccoli just a dish or...