Blake Rushing, PhD

Assistant Professor of Nutrition, Sumner Lab

Blake Rushing, PhD, is an Assistant Professor at the University of North Carolina at Chapel Hill’s Nutrition Research Institute (NRI). Dr. Rushing is trained in pharmacology and toxicology, and has experience using liquid chromatography-mass spectrometry, nuclear magnetic resonance, in vitro model systems, and various biochemical assays to study the interactions between small molecule toxins/drugs with macromolecular targets such as proteins and DNA. He is well versed in using analytical instrumentation to study metabolic products of exogenous small molecule agents and their biological effects. Dr. Rushing earned a BS in Chemistry from Catawba College, and a PhD in Pharmacology and Toxicology in 2018 from East Carolina University. Dr. Rushing conducts research as a member of the Metabolomics and Exposome Laboratory in the Sumner Lab at NRI, and he is an investigator in the NIEHS-funded Human Health Exposure Analysis Resource (HHEAR) program. In these roles, he has determined metabolomic signatures and pathway perturbations associated with human disease (e.g., osteoarthritis), nutrient deficiencies in wild type and knockout animal models (e.g., folate), and cellular response to anti-cancer agents.  Dr. Rushing’s career interests lie in using omics techniques to study how nutrients and other compounds from the diet can be used to enhance the efficacy of drugs or mitigate against their adverse effects.

Collaboration Team

Yuanyuan Li, PhD

Yuanyuan Li, PhD

Assistant Professor of Nutrition, Sumner Lab

yuanli4@unc.edu
704-250-5069

Wimal Pathmasiri, PhD

Wimal Pathmasiri, PhD

Assistant Professor of Nutrition, Sumner Lab

wimal_pathmasiri@unc.edu
704-250-5069

Delisha Stewart, PhD

Delisha Stewart, PhD

Assistant Professor of Nutrition, Sumner Lab

delisha_stewart@unc.edu
704-250-5068

Susan J. Sumner, PhD

Susan J. Sumner, PhD

Professor of Nutrition

susan_sumner@unc.edu
704-250-5066

Publications

2020

Rushing BR, Rohlik D, Roy S, Skaff DA, Garcia, BL. Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery. 2020. Molecules. 25(17): 4016.

Polli JR, Rushing BR, Lish L, Lewis L, Selim MI, Pan X. 2020. Quantitative analysis of PAH compounds in DWH crude oil and their effects on Caenorhabditis elegans germ cell apoptosis, associated with CYP450s upregulation. Science of the Total Environment. https://doi.org/10.1016/j.scitotenv.2020.140639 Online ahead of print.

Mamillapalli S, Smith-Joyner A, Forbes L, McIntyre K, Poppenfuse S, Rushing B, Strom C, Danell A, May L, Kuehn D, Kew K, Ravisankar S. 2020. Screening for Opioid and Stimulant Exposure in Utero via Targeted and Untargeted Metabolomics Analysis of Umbilical Cords. Ther Drug Monit. doi: 10.1097/FTD.0000000000000753. Online ahead of print.

2019

Rushing AW, Rushing BR, Hoang K, Sanders SV, Peloponese JM, Polakowsi N, Lemasson I. 2019. HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I. PLoS Pathogens. 15(6). e1007922

2018

Rushing BR, Selim MI. 2018. Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods. Food and Chemical Toxicology. 124. 81-100.

Rushing BR, Selim MI. 2018. Adduction to arginine detoxifies aflatoxin B1 by eliminating genotoxicity and altering toxicokinetic properties. Oncotarget. 9(4): 4559-4570.

2017

Rushing BR, Selim MI. 2017. Structure and oxidation of pyrrole adducts formed between aflatoxin B2a and biological amines. Chem Res Toxicol. 30(6): 1275-1285.

Starr JM, Rushing BR, Selim MI. 2017. Solvent-dependent transformation of aflatoxin B1 in soil. Mycotoxin Res. 33(3): 197-205.

2016

Rushing BR, Qing H, Franklin JN, McMahen R, Dagnino S, Higgins CP, Strynar MJ, DeWitt JC. 2016. Evaluation of the immunomodulatory effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in C57BL/6 mice. Tox Sci. 156(1): 179-189.

Rushing BR, Selim MI. 2016. Effect of dietary acids on the formation of aflatoxin B2a as a means to detoxify aflatoxin B1. Food Addit Contam Part A. 33(9): 1456-1467.

Rushing B, Wooten A, Shawky M, Selim MI. 2016. Comparison of LC–MS and GC–MS for the Analysis of Pharmaceuticals and Personal Care Products in Surface Water and Treated Waste waters. Current Trends in Mass Spectrometry, a supplement to LCGC North Am., LCGC Europe, and Spectroscopy. 14(3): 8-14.