Susan J. Sumner, PhD
Professor of Nutrition and Pharmacology
Susan Sumner, PhD is a Professor of Nutrition at UNC Chapel Hill’s Nutrition Research Institute (NRI), and the Director of the Metabolomics and Exposome Laboratory (MEL) at UNC Chapel Hill. Dr. Sumner is working to make personalized medicine and precision nutrition a reality. Using state-of-the-art metabolomics and exposome technologies, Dr. Sumner’s team determines how molecules that are present in our tissues and biological fluids are associated with states of health and wellness. Through this approach, biomarkers are discovered that can lead to new diagnostics for the early detection and diagnosis of disease, to monitor treatment and intervention, and to inform the development of intervention strategies.
The Sumner-Lab uses analytical methods to detect tens of thousands of signals for molecules that are present in biological specimens (such as urine, serum, plasma, feces, sweat, tissues, and cells). Using untargeted metabolomics, signals are detected for metabolites that are derived from endogenous metabolic process, such as neurotransmitters, hormones and steroids, sugars, amino acids, purines and pyrimidines, lipids, fatty acids, and vitamins and essential nutrients. Signals are also detected for metabolites derived from a wide range of exposures, including metabolites derived from ingestion of foods, intake of medications or drugs of abuse, and environmentally relevant
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Rachel Coble
Research Technician, Sumner Lab
Rachel Joined the UNC Chapel Hill NRI in August 2020 as a Research Technician in the Sumner Lab. As a local of Rowan County, specifically China Grove, she graduated from Catawba College in 2020 with a B.S. in Biochemistry. She has always wanted to have some kind of involvement at the NCRC ever since she saw the campus being built as a little girl. Now, her dream has come true. She plans to further her involvement in metabolomics during the admirable times here at the NRI.
David Kirchner, MS
Research Associate, Sumner Lab
David Kirchner, MS is a Research Associate in the Sumner-Lab at NRI. He uses his training in mass spectrometry to analyze proteins and metabolites in biospecimens. Mr Kirchner has over 20 years of experience working in laboratories to conduct studies using genetic, molecular and cell biology, bioanalytical chemistry and bioinformatics approaches. He will contribute his knowledge to studies conducted for the Sumner-Lab. Mr. Kirchner earned a MS in Biochemistry from Indiana University of PA in 2010.
Susan McRitchie, MA, MS
Program Manager, Sumner Lab
Susan McRitchie, MA, MS, is the lead biostatistician in the Sumner-Lab at the University of North Carolina at Chapel Hill’s Nutrition Research Institute (NRI). She has over 20 years of experience using statistics and modeling approaches to associate survey data and laboratory measures from basic, clinical, and epidemiology investigations with a wide variety of health outcomes. She served as the Program Coordinator for the NIH-Common Fund Eastern Regional Comprehensive Metabolomics Core (ERCMRC, 2012-2019), and contributed to working groups on data analysis and visualization, and promotion and outreach. She is currently the Program Coordinator for the North Carolina Human Health Exposure Analysis Resource Untargeted Analysis Laboratory (NC HHEAR UAL) that was established in August 2019. Ms. McRitchie’s research interest lies in understanding how diet, and nutrients, can mitigate against adverse effects from exposures to drugs, medications, and environmentally relevant chemicals. Ms. McRitchie earned a MA in Mathematics from UCLA and a MS in Biostatistics from UNC Chapel Hill.
Sabrina Molina
Research Technician, Sumner Lab
Sabrina graduated from UNC Charlotte with a degree in biology, working in a bioinformatics lab during her time there. She began as a student intern in the Sumner lab and is now working as a research technician, with a goal of pursuing a masters or doctoral degree in nutrition. She is very excited to continue working with all the amazing people at the NRI. In her spare time, Sabrina enjoys cooking, kayaking, and dirt biking.
Wimal Pathmasiri, PhD
Assistant Professor of Nutrition
Wimal Pathmasiri, PhD is an Assistant Professor at the University of North Carolina at Chapel Hill’s Nutrition Research Institute (NRI). An overarching goal of Dr. Pathmasiri’ s research includes understanding the links between exposures (diet, constituents in natural projects, environmental chemicals, drugs), microbial metabolism, and human health. He was worked with the Sumner-Lab for over 12 years, as the director of a technology core for the NIH Common Fund Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC), and as a co-investigator in the North Carolina Human Health Exposure Analysis Resource Untargeted Analysis Laboratory (NC HHEAR UAL). Learn more.
Blake Rushing, PhD
Assistant Professor of Nutrition
Blake Rushing, PhD, is an assistant professor of nutrition at the University of North Carolina at Chapel Hill’s Nutrition Research Institute (NRI). Dr. Rushing’s is trained in pharmacology and toxicology, and has experience using liquid chromatography-mass spectrometry, nuclear magnetic resonance, in vitro model systems, and various biochemical assays to study the interactions between small molecule toxins/drugs with macromolecular targets such as proteins and DNA. He is well versed in using analytical instrumentation to study metabolic products of exogenous small molecule agents and their biological effects. Learn more.
Delisha Stewart, PhD
Assistant Professor of Nutrition
Delisha Stewart, PhD is an Assistant Professor at the University of North Carolina at Chapel Hill’s Nutrition Research Institute. Dr. Stewart has over 10 years of experience using genomics, metabolomics and high-throughput molecular bioassays to investigate mechanisms involved in cancer and inflammation. Dr. Stewart’s primary research includes a portfolio of studies aimed at understanding the impact of diet (high fat, high carbohydrate) on weight gain, and breast cancer endpoints. She uses both in vitro and in vivo model systems of genetic diversity to gain insights into health disparities associated with cancer endpoints. Learn More
The North Carolina Human Health Exposure Analysis Resource Hub (NC HHEAR Hub)
Metabolomics and Exposome Laboratory (MEL) for the following NIH Centers
Nutritional Pharmacology/Toxicology
Choline and Related Metabolites in Nutrition Research
Metabolomics: Using In Vitro Models to Reveal Mechanisms of Cellular Response
Recent Grants Supported by the Metabolomics and Exposome Laboratory (MEL)
R01HL143885 (Sumner, MPI, UNC-CH): 2019–2023
NHLBI
Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseases.
1U01CA235507 (Du, PI, UNC-Charlotte): 2018–2022
NCI
Cross-Platform and Graphical Software Tool for Adaptive LC/MS and GC/MS Metabolomics Data Preprocessing
1R37CA226969-01 (Bae-Jump, PI, UNC-CH): 2018–2023
NCI
Obesity-driven Metabolic and Molecular Biomarkers of Metformin Response in Endometrial Cancer
1R21CA235029-01 (Smith-Ryan & Bae-Jump, MPI, UNC Chapel Hill): 2019–2020
NCI
Interval Exercise Training as a Therapy for Endometrial Cancer
1U01OH011300-01A1 (Nolan, PI, NYUSOM): 2017– 2023
NIOSH
Metabolomics of World Trade Center-Lung Injury
1R01DK115380-01 (Zeisel, PI, UNC Chapel Hill): 2017- 2021
NIDDK
Developing a Biomarker Panel to Assess Choline Nutritional Status
U01ES027254 (Sumner, MPI, UNC Chapel Hill): 2016–2021
National Institute of Environmental Health Sciences
Early-life END exposure and the impact on neurobehavioral, cardiovascular, and biochemical mechanisms.
5UG3OD023275 (Karagas, PI, Dartmouth College): 2016-2023
National Institute of Environmental Health Sciences
Environmental Influences of Child Health Outcomes (ECHO) Pediatrics Cohort
New Hampshire Birth Cohort
5UG3OD023305 (Trasande, PI, NYU School of Medicine): 2016-2023
National Institute of Environmental Health Sciences
Environmental Influences of Child Health Outcomes (ECHO) Pediatrics Cohort
NYU Pediatric Obesity, Metabolism and Kidney Cohort Center
R01DK110077 (Smoyer, PI, Nationwide Children’s Hospital) 2017-2022
NIDDK
Integrating Proteomics and Metabolomics to Understand Pediatric Glomerular Disease
1R21HD087878-01A1 (Harville, PI, Tulane): 2017-2019
NICHD
Preterm birth, pre-eclampsia, and the exposome
Precision nutrition improves health at individual level, expert says
Susan Sumner, PhD, is a professor of Nutrition and pharmacology at the UNC Nutrition Research Institute. Using state-of-the-art metabolomics and exposome technologies, Sumner’s team determines how molecules that are present in our tissues and biological fluids are...
Faculty Focus: Wimal Pathmasiri, PhD
Metabotyping for Better Health For 12 years, Wimal Pathmasiri, PhD, has been conducting metabolomics research to understand the links between exposures, microbial metabolism, and human health. His specific field of study is biomarker identification by metabolic...
NGx: A short course in Nutrigenetics, Nutrigenomics and Precision Nutrition – Day Two
The NRI presented its annual NGx short course May 16-19, in Concord, NC, for graduate students, health professionals, and nutrition scientists. See recap of Day One. On Day Two of the short course, attendees heard from experts on using nutrigenetics, nutrigenomics,...
NRI Trainees Climbing the Ladder of Success
A core objective of the NRI is to provide training opportunities to the next generation of researchers in precision nutrition, including graduate and undergraduate students. These young researchers, selected from the tops of their classes, are mentored by the NRI’s...
Homegrown: Local Graduates Excel at the NRI
Madison Schroder Mooresville, NC B.S. Chemistry, UNC-Chapel Hill Rachel Coble China Grove, NC B.S. Biochemistry, Catawba College For many members of this community, the North Carolina Research Campus (NCRC) is a relatively new sight in Kannapolis. Before the NCRC...
North Carolina Research Campus team receives major NIH award for precision nutrition research
KANNAPOLIS, N.C., January 27, 2022 – The National Institutes of Health (NIH) has awarded a $19.2 million 5-year grant, pending the availability of funds, to a consortium of North Carolina university researchers who will apply cutting-edge analytical techniques to...
UNC nutrition experts uncover structure of enzyme that could aid in disease treatment, prevention
This article was published originally by the Gillings School of Global Public Health on January 25, 2022. New findings from researchers at the UNC Nutrition Research Institute (NRI) have revealed the structure of an enzyme that plays a key role in predicting whether a...
Student Success at the NRI: Alleigh Wiggs, Breast Cancer Researcher and Advocate
Congratulations to Alleigh Wiggs, a student researcher with the Sumner Lab, whose research on the effects of diet and exercise on endogenous estrogens and subsequent breast cancer risk in postmenopausal women was recently published in Frontiers in Endocrinology....
2023 Publications
2022 Publications
2022
Commonalities in Metabolic Reprogramming between Tobacco Use and Oral Cancer
Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants
Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty
Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice
Dietary Supplements for Athletic Performance in Women: Beta-Alanine, Caffeine, and Nitrate
Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast.
2021 Publications
2021
Emerging technologies and their impact on regulatory science
Bridging the Gap Between Analytical and Microbial Sciences in Microbiome Research
Associations between the gut microbiome and metabolome in early life
Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1
Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction
Metabolomics reveals biomarkers of opioid use disorder
Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients
2020 Publications
2019 Publications
Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Proteomics.
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver.
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome.
Health-related quality of life in glomerular disease.
Human PAH is characterized by a pattern of lipid-related insulin resistance.
Metabolomics for Biomarker Discovery and to Derive Genetics Links to Disease.
2018 Publications
Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity.
Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue.
Using Metabolomics to Investigate Biomarkers of Drug Addiction.
Human microbiota, blood group antigens, and disease.
Effect of endotoxin and alum adjuvant vaccine on peanut allergy.
2017 Publications
2016 Publications
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice.
Metabolomics enables precision medicine: “A White Paper, Community Perspective”.
Impact of a western diet on the ovarian and serum metabolome.
Blood type biochemistry and human disease.
The Importance of the Biological Impact of Exposure to the Concept of the Exposome.