Genes and Nutrition
Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?
NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.
Publications
Genes and Nutrition Publications
2020
Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Voruganti VS
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
2019
DNA methylation in mice is influenced by genetics as well as sex and life experience. French J
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Krupenko S
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. Krupenko S
Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study. Voruganti VS
Heterogeneity in Metabolic Responses to Dietary Fructose. Voruganti VS
Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. Voruganti VS
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Voruganti VS
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies. Voruganti VS
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Voruganti VS
2018
C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Krupenko N
Nutritional Genomics of Cardiovascular Disease. Voruganti VS
Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study. Voruganti VS
Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Voruganti VS
Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Voruganti VS
Dietary Modulation of the Epigenome. Zeisel S
2017
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. Voruganti VS
Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. Voruganti VS
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Zeisel S
Choline, Other Methyl-Donors and Epigenetics. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. Zeisel S
Related News
Celebrating and Preparing in A Milestone Year
January 25, 2019 – As we at the NRI celebrate our tenth anniversary year, we are also taking measures to secure our longevity. Our world-class research facility on the North Carolina Research Campus opened in 2008 with the most advanced equipment, instrumentation, and laboratories available. Now, as we enter a second decade, administrators are evaluating our building, systems, and staffing to ensure that our scientists have the best infrastructure to allow them to continue their quest for new precision nutrition discoveries.
June 2019
The DNA Diet: Knowing How Your Genes Can Help You Fit Into Your Jeans May 20, 2019 – How are we expected to make healthy choices about food when the headlines are so confusing? We all suffer whiplash when we read butter is bad, then butter is good; when red meat is...
The Choices I.C.A.N. Make
January 25, 2019 – Pregnant women are often consumed by dietary choices such as finding a great prenatal vitamin, eating foods that will promote fetal growth, and doing everything they can to protect their pregnancy. After delivery, however, the mother’s preoccupation with her diet often pauses for four to six months. The Cheatham Nutrition & Cognition Lab is turning this type of thinking on its head with the belief that what women eat while breastfeeding greatly impacts their breastmilk and ultimately, their children’s development.
January Faculty Focus: Philip May, PhD
January 11, 2019 – “I’ve been called ‘tenacious’,” says Philip A. May, PhD, with a hint of humor. It’s an understatement for the man who relentlessly pursues data that shed light on important public health issues across the United States and around the globe. May, professor of nutrition at the UNC Nutrition Research Institute (NRI) and in the Department of Nutrition at the Gillings School of Global Public Health at UNC-Chapel Hill, has been a demographer and epidemiologist for the better part of 50 years. He calls his style of research “shoe-leather” epidemiology, meaning that he gathers information for studies by getting out in the field and immersing himself in communities to really know the people in his studies. For nearly 30 of those years, May’s focus has been on learning about the often-dire effects and alarmingly high prevalence of fetal alcohol exposure.
Women’s Health, Preconception Nutrition, and the Right to Choose
December 16, 2018 – If you’ve ever been around a pregnant woman, you’ve probably heard her mention something about food cravings. Or she’s mentioned that she won’t drink coffee or eat Oreos because they are “bad for the baby.” Food is a hot topic during pregnancy because of how it can drastically affect the developing baby. But how many times have you heard a woman mention that she is eating healthier because she is going to try to get pregnant?
December Faculty Focus: Susan Sumner, PhD
December 15, 2018 – Through the ages, science has often been in the company of poetry. They came together recently when Susan Sumner, PhD, described how she got her start in Biomarker Discovery using spectroscopic methods as an undergraduate at North Carolina State University (NCSU): “I found it exciting to envision molecules dancing in multidimensional space in response to applied physical factors such as magnets, radio frequency pulses, or electric fields.”