Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

July 2016

The Sweet Reality of Eating Nutritious Fruits This time of year, fresh fruits abound. No matter whether the fruit you eat is fresh, canned, frozen, or dried, all of the varieties offer a plethora of flavors, colors and, most importantly, health benefits. No...

NRI welcomes renowned scientist to Kannapolis institute

June 27, 2016 • The UNC Nutrition Research Institute (NRI) welcomes Susan Smith, Ph.D., who joins the research facility’s roster of scientists this month. Dr. Smith is an internationally recognized expert on how nutrition affects birth defect risks.

The Sweet Reality of Eating Nutritious Fruits

June 23, 2016 • This time of year, fresh fruits abound. No matter whether the fruit you eat is fresh, canned, frozen, or dried, all of the varieties offer a plethora of flavors, colors and, most importantly, health benefits.

Faculty and Research Opportunities

June 22, 2016 • The UNC Nutrition Research Institute offers opportunities for faculty and researchers to refine or expand a nutrition-related research program. The Institute is particularly interested in research related to nutrigenomics, metabolomics, epigenetics, clinical nutrition and/or energy expenditure.
Learn more about Faculty Fellows and Visiting Scholars.

Sweet Potato Slaw

June 21, 2016 • Sweet Potato Slaw by Chef Aubrey Mast of the NC State Plants for Human Health Institute.

Employee Ice Cream Social

Join the morale committee on Thursday, July 14 for an Ice Cream Social. A special Ice Cream Truck will be coming to the NRI with FREE ice cream for all NRI employees! Registration required. Thursday, July 14, 2 - 3:30 PM [gravityform id="18" title="false"...