Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes
Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes.
Strickland KC, Holmes RS, Oleinik NV, Krupenko NI, Krupenko SA.
Chem Biol Interact. 2011 May 30;191(1-3):122-8. doi: 10.1016/j.cbi.2010.12.025. Epub 2011 Jan 6.
PMID: 21215736
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.
Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA.
J Biol Chem. 2010 Jul 23;285(30):23056-63. doi: 10.1074/jbc.M110.128843. Epub 2010 May 24.
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Acyl carrier protein-specific 4′-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase
Acyl carrier protein-specific 4′-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.
Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA.
J Biol Chem. 2010 Jan 15;285(3):1627-33. doi: 10.1074/jbc.M109.080556. Epub 2009 Nov 20.
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Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6
Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6.
Hoeferlin LA, Fekry B, Ogretmen B, Krupenko SA, Krupenko NI.
J Biol Chem. 2013 May 3;288(18):12880-90. doi: 10.1074/jbc.M113.461798. Epub 2013 Mar 21.
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January 2015
Clinical Studies at the Nutrition Research Institute The Nutrition Research Institute is committed to conducting innovative, basic and translational science to support the understanding of individualized nutrition. These advances in science promote the prevention and...
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans.
Kohlmeier M, da Costa KA, Fischer LM, Zeisel SH.
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16025-30. Epub 2005 Oct 18.
PMID: 16236726