Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
High fat diet-induced maternal obesity alters fetal hippocampal development
Niculescu, M. D., and Lupu, D. S. (2009) High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci 27, 627-633
Choline in Health and Disease in Vitamins in the Prevention of Health Disease
Teng, Y-W, Zeisel, S.H. (2010) Choline in health and disease In Vitamins for the Prevention of Human Disease, Edited by W. Herrmann, R. Obeid, Walter De Gruyter GMBH & Co, Berlin, Germany. 599-612.
Cardiac involvement in trichinellosis: a case of left ventricular thrombosis
Tint, D., Cocuz, M. E., Ortan, O. F., Niculescu, M. D., and Radoi, M. (2009) Cardiac involvement in trichinellosis: a case of left ventricular thrombosis. Am J Trop Med Hyg 81, 313-316
Berries and Brain: Partners in Life and Longevity
Carol Cheatham, Ph.D. and Kelly Sheppard, Ph.D.
A Grand Challenge for Nutrigenomics
Zeisel, S.H. (2010) A Grand Challenge for Nutrigenomics. Frontiers in Nutrigenomics.
Nutritional Genomics Defining the Dietary Requirement and Effects of Choline
Zeisel, S.H. (2010) Nutritional Genomics Defining the dietary requirement and effects of choline. The Journal of Nutrition. 531-534.