Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

NRI Welcomes New Researcher Dr. Martin Kohlmeier

Internationally-renowned researcher and author, Martin Kohlmeier, M.D., Ph.D., has relocated to Kannapolis to join the NRI team. Dr. Kohlmeier’s many accomplishments include developing consumer software about healthy foods and online nutrition education for medical students.

Keimyung University Researcher Partners with NRI

Dr. Seung-Wan Ryu, Associate Professor in Department of Gastrointestinal Surgery at the Keimyung University School of Medicine in Korea, is visiting the NRI to collaborate on cutting edge nutrition research. Dr. Ryu is studying the effects of dietary choline on the growth of blood vessels in tumors.

Study Reveals Diet Rich in choline Promotes Fetal Brain Development

A mouse study by NRI scientists shows that prenatal diets that are deficient in choline—an essential nutrient that is part of all cell membranes— form fewer blood vessels in the brains of developing fetuses. These findings could prove significant for pregnant women.

NRI Scientist Joins International Public Education Campaign

Dr. Carol Cheatham, developmental cognitive neuroscientist with the NRI, is a featured expert with an international public education campaign. Sponsored by Abbott Nutrition, the makers of Similac infant formula, the campaign was designed to promote awareness of proper nutrition for pregnant women in Vietnam and Singapore.

NRI Director Heads GenoVive Scientific Advisory Board

As chair of GenoVive’s Scientific Advisory Board, Dr. Steven Zeisel, director of the NRI, will provide strategic guidance to this private corporation. GenoVive scientists develop customized meal and exercise programs that are based on individual DNA.