Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

Related News

Caramelized Pear, Roasted Tomato and Lentil Salad

Caramelized Pear, Roasted Tomato and Lentil Salad

December 29, 2017 – This fresh New Year salad combines the natural sweetness of caramelized pear and roasted tomato, with earthy lentils and tender butter lettuce. Finished with lemon zest, olive oil and balsamic vinegar, this elegant salad lends starts the New Year off on a healthy note.

Quinoa Compounds Slow Aging, Improve Metabolic Health in Animal Study

Quinoa Compounds Slow Aging, Improve Metabolic Health in Animal Study

December 27, 2017 – In a collaboration between Rutgers University and the N.C. State University Plants for Human Health Institute (PHHI) at the NC Research Campus (NCRC), scientists used an animal model to show for the first time that quinoa phytochemicals, such as ecdysteroids, may slow the effects of aging and improve metabolic health. Their study was published in the October 2017 edition of the Journal of Functional Foods.

December 2017

Choline: The essential but forgotten nutrient November 27, 2017 – Perhaps it’s because you don’t see it on nutrition labels yet, but choline — an essential nutrient from conception through old age — tends to be tragically overlooked. According to data from the...

Choline: The essential but forgotten nutrient

November 27, 2017 – Perhaps it’s because you don’t see it on nutrition labels yet, but choline — an essential nutrient from conception through old age — tends to be tragically overlooked. According to data from the National Health and Nutrition Examination Survey, only 1 in 10 of us get enough choline, and those percentages drop among women during pregnancy — right when they need it most.

Why Iron Man’s mother didn’t drink alcohol during pregnancy

November 27, 2017 -In the Marvel movie Iron Man, Tony Stark (Iron Man) is a genius inventor who creates a suit of armor, giving himself enhanced strength and the ability to fly. Although Tony Stark carries the name “Iron Man” for his suit of metal armor, his name is also an apt description of the abundance of iron that he has in his body, especially in his brain. The human body requires iron to function normally, and without enough iron, adults feel fatigued and have difficulty concentrating. Iron is even more essential during pregnancy. If Tony Stark’s mother had not consumed enough iron during pregnancy, it is unlikely that he would have become a brilliant inventor, because iron is necessary for the proper development of the infant’s brain.