Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
Do Eggs Cause Heart Disease?
October 25, 2016 • Several recent studies linked increased levels of a metabolic product of dietary choline with higher risk of cardiovascular disease (CVD) (Wang et al., 2011; Tang et al., 2013) through a mechanism that involved gut microbiota-produced trimethylamine oxide (TMAO). These studies have sparked considerable scientific (and non-scientific) discussion, with health advice from some groups suggesting avoidance of meat and eggs (significant sources of choline) and from others suggesting that the findings have been vastly overinterpreted.
Sugar-Sweetened Beverages Increase Risk for Hyperuricemia
October 25, 2016 • According to the CDC, sugar-sweetened beverages are the largest source of added sugar in the average American’s diet, and the Dietary Guidelines for Americans recommend individuals consume no more than ten percent of calories per day from processed or added sugar. From the UNC Chapel Hill Nutrition Research Institute (NRI), scientists are investigating the connection between these beverages, human genetics, and uric acid metabolism.
October 2016
NRI Researcher Links Choline Deficiency to Impaired Brain Structure Natalia Surzenko, Ph.D., is part of a team of researchers at the UNC-Chapel Hill Nutrition Research Institute (NRI) located on the North Carolina Research Campus (NCRC) in Kannapolis focusing their...
NRI Researcher Links Choline Deficiency To Impaired Brain Structure
September 21, 2016 • Natalia Surzenko, Ph.D., is part of a team of researchers at the UNC-Chapel Hill Nutrition Research Institute (NRI) located on the North Carolina Research Campus (NCRC) in Kannapolis focusing their efforts on brain development. Her current goal is to determine the role of choline as an essential nutrient for development of the cerebral cortex.
Hungry for more? Food theme serves a second helping this fall
September 20, 2016 • Food For All, Carolina’s pan-University academic theme, didn’t take a summer break, said the co-chairs of the theme’s steering committee. And the theme will serve up even more this fall, including a speaker series, a summit to propose a statewide food policy and a new food studies class.
Corporate Event: December 1, 2016
You're invited to eat with the Nutrition Research Institute. Join business colleagues and learn why we explore personalized nutrition and how it impacts brain development and memory, and obesity-related diseases like cancer, heart disease and diabetes. ...