Genes and Nutrition
Each of us is metabolically unique. Gene variations known as SNPs (single nucleotide polymorphisms) often are a factor in an individual’s ability to metabolize or use nutrients efficiently. Each of our specific nutrient needs is affected by which specific combination of SNPs we have, but with thousands known to impact nutrition metabolism, how do we know what those needs are?
NRI researchers are working to create a “catalog” of SNPs that alter our nutritional needs by understanding how genetic and other complex biological information can be used to better estimate individual nutrition requirements and intolerances. Our scientists use bioinformatics to extract such information from population and intervention studies, develop rules for predicting individual needs, and bring precision nutrition to health care providers and consumers with digital tools.
Publications
Genes and Nutrition Publications
2020
Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Voruganti VS
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
2019
DNA methylation in mice is influenced by genetics as well as sex and life experience. French J
Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Krupenko S
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome. Krupenko S
Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study. Voruganti VS
Heterogeneity in Metabolic Responses to Dietary Fructose. Voruganti VS
Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study. Voruganti VS
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Voruganti VS
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies. Voruganti VS
Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Voruganti VS
2018
C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Krupenko N
Nutritional Genomics of Cardiovascular Disease. Voruganti VS
Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study. Voruganti VS
Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Voruganti VS
Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Voruganti VS
Dietary Modulation of the Epigenome. Zeisel S
2017
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. Voruganti VS
Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. Voruganti VS
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Zeisel S
Choline, Other Methyl-Donors and Epigenetics. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. Zeisel S
Related News
The Invisible Middle of Research
At the UNC Nutrition Research Institute, discovery does not happen in a single moment. Between the first research question and the final publication is the careful, often unseen work of planning, recruiting participants, gathering data, building teams, and refining ideas. This invisible middle is where science takes shape.
Whole Grain Study
Study Purpose: We want to invite you to participate in a research project to conduct a study to identify biomarkers of whole-grain corn intake through a pharmacokinetic (how a substance is absorbed, distributed, metabolized, and eliminated by the body over time)...
Natalia Krupenko, PhD, and Stephen Hursting, PhD, named 2026 Excellence in Nutrition Fellows of the American Society for Nutrition
The UNC Nutrition Research Institute is proud to celebrate Natalia Krupenko, PhD, and Stephen Hursting, PhD, MPH, who have been named 2026 Excellence in Nutrition Fellows of the American Society for Nutrition.
The FASN designation recognizes distinguished members of ASN for their ongoing contributions to the field of nutrition and sustained engagement in the nutrition community. For Krupenko and Hursting, the honor reflects not only individual achievement, but also the long-term impact of research that is helping shape how scientists understand the relationship between nutrition, metabolism, chronic disease, and lifelong health.
The Making of a Scientist: Halle Meyers’s NRI Experience
Halle Meyer’s journey at the UNC Nutrition Research Institute began in 2020, when she joined the institute as a 21-year-old research technician in the lab of Sergey Krupenko, MD, PhD. Nearly six years later, she successfully defended her dissertation, earned her PhD in Nutrition from UNC-Chapel Hill, and leaves the NRI with not only scientific expertise, but a deep appreciation for the community and mentorship that shaped her along the way.
NGx Highlights NRI’s Pioneering Role in Precision Nutrition and Exercise Across the Lifespan
Dr. John Batsis Brings Expertise in Aging, Obesity, and Clinical Research to the NRI
NGx brings together forward-thinking minds at the intersection of nutrition, genetics, and health to explore where science is going next—and how it’s already shaping the way we understand and apply precision nutrition. This is more than a conference; it is a chance to engage directly with the research, the people behind it, and the ideas that are redefining the field.






