Microbiome and Nutrition

The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.

Publications

 

Microbiome and Nutrition Publications

2020

Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K

2019

Association of dietary patterns with the gut microbiota in older, community-dwelling men.  Meyer K

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes.  Sumner S

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).  Zeisel S

2018

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.  Meyer K

Human microbiota, blood group antigens, and disease.  Sumner S

2017

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies.  Meyer K

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.  Sumner S

Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic.  Sumner S

Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.  Zeisel S

2016

Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).  Meyer K

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.  Meyer K

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S

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Amtrak Shuttle

Please note that we are discontinuing our taxi reservation service immediately due to low use and poor service by the company we contracted with. We ask that you coordinate your own reservations moving forward, and provide a receipt for the taxi service when you turn...

July 2015

July 2015 SoundBites features: The “-omics” of Nutrient Metabolism, Research We’re Reading: Go with Your Gut, Summer Tours and Fall Events

The Longevity Diet

https://www.youtube.com/watch?v=pLTJQEROMtA&feature=youtu.be

August 2015

August 2015 SoundBites features: Healthy Eyes at Every Age, Last Chance to Tour the NRI, and Cooking for Nourishment: Demo + Talk

Healthy Eyes at Every Age

Healthy Eyes at Every Age

July 22, 2015 • Speakers at the recent Institute of Food Technologists meeting in Chicago in July discussed an essential nutrient that plays a vital role in human health. Unfortunately, few people have heard of it and fewer still are eating enough of it.
“Choline is an essential but widely under-consumed nutrient,” says Catherine Adams Hutt, registered dietician and science and nutrition advisor to The Choline Information Council®. “Only children typically get enough choline and most adults, including pregnant and lactating women, don’t get as much choline as they need. Just as choline is essential in the development of the brain, it is also critical for the development of the mechanics of our eyes,” she adds.

The “-omics” of Nutrient Metabolism

July 1, 2015 • How our bodies use the nutrients that nourish us drives much of the science at the Nutrition Research Institute. Recent advances in nutrition studies have shed light on the metabolic fates of nutrients and about the molecular actors and mechanisms responsible for the underlying processes. A major reason for the explosive advances in the understanding of nutrient metabolism has been the massive investigative use of all kinds of “-omics,” new fields of study for the mining of data-rich biological information.