Microbiome and Nutrition
The complex community of bacteria, yeasts and viruses living in our intestines, collectively known as the gut microbiome, is shaped, in part, by what we eat. Genetics, environment, and other factors also influence an individual’s microbial community. Research at the NRI investigates these complex relationships and their impact on disease risk. We use animal models and bioinformatics to study the associations between nutritional metabolites, gut microbiome, and health. What happens in the gut doesn’t stay in the gut. Your microbiome can play a role in cardiovascular disease, obesity and diabetes, and even cancer. Our team envisions a future where analysis of your microbiome can determine disease risk, and medical foods can be prescribed to treat and prevent disease by regulating the microbiome.
Publications
Microbiome and Nutrition Publications
2020
Population studies of TMAO and its precursors may help elucidate mechanisms. Meyer K
2019
Association of dietary patterns with the gut microbiota in older, community-dwelling men. Meyer K
2018
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Meyer K
Human microbiota, blood group antigens, and disease. Sumner S
2017
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease. Zeisel S
2016
Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk. Meyer K
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice. Sumner S
Related News
AFL@JWU Nutrition Notes – October 17, 2018
October 17, 2018 – The science on food and nutrients and their relationship to health is complex. Individuals are unique and there are various factors that influence health outcomes. Researchers at the UNC Nutrition Research Institute (NRI) are working very hard to understand the intricacies of diet and nutrients, and their relationship to disease prevention and progression with the goal that general dietary guidance will be replaced with personalized nutrition recommendations.
Breaking the Link Between Obesity, Gastrointestinal Cancers
October 3, 2018 – UNC NRI’s and UNC Lineberger’s Stephen Hursting, PhD, MPH, along with Cornelia Ulrich, PhD, MS, the director of the Huntsman Cancer Institute’s National Cancer Institute-designated Comprehensive Cancer Center, and colleagues, reviewed findings from research looking at the biological links between obesity and cancers of the colon, rectum, pancreas, liver, esophagus, gallbladder and stomach, as well as published studies on how diet, exercise, weight loss surgery, and other weight-related interventions may help reverse this connection.
October Faculty Focus: Saroja Voruganti, PhD
October 17, 2018 – Saroja Voruganti, PhD, has covered a lot of ground in her journey to becoming a faculty researcher in nutrition, genetics, and epidemiology at the UNC Nutrition Research Institute. Born into a traditional south Indian family, she grew up in Delhi in northern India where she graduated with an undergraduate degree in nutrition. Then she married and moved to western India. Even as she focused on marriage, home, and raising a family in the traditional Indian way of life, she kept alive her dream of pursuing advanced studies and contributing outside of family life.
Choline in Human Milk Plays a Crucial Role in Infant Memory
October 3, 2018 – Choline is present in human milk, and is especially important for fetal and infant development [2,3]. “The hint that choline is important for infant development comes from the fact that in human milk, the supply of choline remains constant across the first year of life,” says Professor Carol Cheatham from the University of North Carolina at Chapel Hill. Other important nutrients, such as docosahexaenoic acid (DHA), are present in large quantities initially, but often level off after a few months.
Culinary twist: Healthy food that helps the community
September 28, 2018 – Good Bowls taps into the UNC innovation network and brings locally sourced meals to lower-income consumers. Social innovation is nothing new at the University of North Carolina at Chapel-Hill. And using its long history of social innovation as a cornerstone, one UNC venture is blazing a trail to improve community health. If you haven’t already heard of Good Bowls, you will.
Celebrating a Decade of Nutrition Discoveries
September 28, 2018 – This October, the NRI proudly marks its tenth anniversary of delving into the science of Precision Nutrition. What began in 2008 with two faculty members and a supporting staff of nine is, today, a bustling center of scientific inquiry and discovery with a staff of 82, which includes 16 principal investigators.