NSAID use reduces breast cancer recurrence in overweight and obese women: role of prostaglandin-aromatase interactions.
Bowers LW, Maximo IX, Brenner AJ, Beeram M, Hursting SD, Price RS, Tekmal RR, Jolly CA, deGraffenried LA.
Cancer Res. 2014 Aug 15;74(16):4446-57. doi: 10.1158/0008-5472.CAN-13-3603.
PMID: 25125682
Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production.
Bowers LW, Brenner AJ, Hursting SD, Tekmal RR, deGraffenried LA.
Breast Cancer Res Treat. 2014 Dec 5. [Epub ahead of print]
PMID: 25476497
May 20, 2019 – Research findings presented at the American Association for Cancer Research Annual Meeting 2019 explore possible reasons for obesity-related resistance to breast cancer treatment and possible strategies to overcome obesity-related immune suppression in cancer.
August 30, 2018 – While the link between obesity and breast cancer risk is well known, the underlying mechanisms are not fully understood. Obesity alters many conditions in cells and within the body, and it is not easy to determine which of these conditions are important to the obesity-cancer link. Consequently, it is very difficult to identify potential therapeutic targets.
April 26, 2018 -About one third of cancer cases are estimated to be linked to dietary and other modifiable risk factors, especially for obesity-related cancers such as breast, colorectal, ovarian, endometrial, kidney, gallbladder, esophageal, and pancreatic cancers. In this special theme issue of the Journal of the Academy of Nutrition and Dietetics, food and nutrition practitioners and other health professionals take an in-depth look at the relationship between nutrition, obesity, and cancer prevention, treatment, and survival and identify research gaps for future prevention research efforts.