Environment and Nutrition
Beginning at conception, environmental factors in health can accumulate over a lifetime and be from sources as broad as geographic location and economic status to specific external sources including physical activity, occupation, risky behaviors and diet. But some of these factors, especially in terms of diet are highly modifiable.
Important research is now being conducted on this concept of the “exposome,” as an environmental complement to the human genome. NRI researchers are learning how diet and other environmental exposures interact with disease and affect responses to treatment.
Publications
Environment and Nutrition Publications
2020
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity. Zeisel S
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Zeisel S
2019
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Hursting S
When less may be more: calorie restriction and response to cancer therapy. Hursting S
Energy balance and obesity: what are the main drivers? Hursting S
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Early-Life Predictors of Fetal Alcohol Spectrum Disorders. May P
Alcohol’s Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. Smith S
2018
Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms. Hursting S
Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention. Hursting S
2017
Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype. Krupenko S
Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Zeisel S
2016
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. Krupenko N
Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. Smith S
Impact of a western diet on the ovarian and serum metabolome. Sumner S
Metabolomics enables precision medicine: “A White Paper, Community Perspective”. Sumner S
Related News
How Diet Enhances Our Natural Anti-Cancer Response
September 28, 2017 One of the ways the body controls the overall number of cells is by initiating a preprogrammed cell death routine, known as apoptosis, in damaged or otherwise unnecessary cells. Apoptosis allows elimination of cells without induction of an autoimmune response. A hallmark of many types of cancer cells is a resistance to apoptosis; hence, tumors continue to grow and metastasize. Finding ways to defeat this resistance in cancer cells is an area of active research.
Polyphenols: Colorful, Healthy, Plant Compounds You May Already Eat & Drink
September 28, 2017 – Many of the foods you eat are loaded with polyphenols: plant-based compounds that are anti-oxidant, anti-inflammatory and anti-infection. Polyphenols are considered non-nutritional, meaning that they help prevent disease and keep you healthy in a different way than vitamins, minerals, or other nutrients like carbohydrates, fats, and protein. David Nieman, DrPH, director of the Appalachian State University Human Performance Lab at the North Carolina Research Campus (NCRC), explains that polyphenols are a type of phytochemical, the colorful chemicals in plants that confer a variety of health benefits. “In many fruits and vegetables, all the colors that you see are the polyphenols,” he says. “That’s what you want, a lot of color in your diet.”
September 2017
The Ironies of Iron During Pregnancy Iron is listed by the American Pregnancy Association as one of the nutrients essential for healthy fetal development. Why? Because a lack of iron, a mineral naturally found in foods like meat, seafood and vegetables, directly...
Build Stronger Muscles with All Kinds of Protein
August 28, 2017 – From the desks of Martin Kohlmeier, MD, PhD and Robyn Amos-Kroohs, PhD
Protein is an important part of every cell in the body. Protein is also a building block of enzymes, hormones, and other important substances used in body processes. It’s a major component of most body systems, including the immune system, metabolism, and circulatory system. Its importance is why protein is known as a macronutrient, meaning that large amounts are required to help the body function appropriately on a daily basis. And unlike sugar and fats, macronutrients that have acquired bad reputations, protein is recognized as an important part of a healthy diet.
The Ironies of Iron During Pregnancy
August 28, 2017 – Iron is listed by the American Pregnancy Association as one of the nutrients essential for healthy fetal development. Why? Because a lack of iron, a mineral naturally found in foods like meat, seafood and vegetables, directly impacts the development of the fetal brain. Iron also prevents anemia, low birth weight and premature delivery. Unfortunately, 22 percent of US women in their childbearing years are iron deficient, says Susan Smith, PhD, deputy director of science at the UNC Nutrition Research Institute on the NC Research Campus.
UNC-CH Nutrition Research Institute Graduate Student Housing Opens Steps Away from NCRC Main Campus
June 27, 2017 • The Nutrition Research Institute (NRI) offers unique learning and work experiences for graduate students in the fields of nutrigenomics and metabolomics. Our research relies, in fact, on the work these students do. But until recently the institute has been short on student housing, creating hardship for those who wished to study and work here. That has changed with the opening of five newly refurbished houses a short walk from the institute and the rest of the North Carolina Research Campus, offering both short- and long-term student housing options.