May 20, 2019 – Research findings presented at the American Association for Cancer Research Annual Meeting 2019 explore possible reasons for obesity-related resistance to breast cancer treatment and possible strategies to overcome obesity-related immune suppression in cancer.
November 20, 2018 – Nutrient availability regulates cell metabolism, growth, and survival. When nutrients are in short supply, cells can pause their growth or even eliminate themselves through a process known as programmed cell death, thereby protecting the health of the organism as a whole. If nutrient deprivation happens at certain critical periods, such as during the rapid growth of the embryonic brain, severe developmental consequences can arise (this is why proper maternal nutrition is so important). In contrast, harnessing the innate ability of cells to enter programmed cell death is an important strategy in cancer treatment.
October 3, 2018 – UNC NRI’s and UNC Lineberger’s Stephen Hursting, PhD, MPH, along with Cornelia Ulrich, PhD, MS, the director of the Huntsman Cancer Institute’s National Cancer Institute-designated Comprehensive Cancer Center, and colleagues, reviewed findings from research looking at the biological links between obesity and cancers of the colon, rectum, pancreas, liver, esophagus, gallbladder and stomach, as well as published studies on how diet, exercise, weight loss surgery, and other weight-related interventions may help reverse this connection.
August 30, 2018 – While the link between obesity and breast cancer risk is well known, the underlying mechanisms are not fully understood. Obesity alters many conditions in cells and within the body, and it is not easy to determine which of these conditions are important to the obesity-cancer link. Consequently, it is very difficult to identify potential therapeutic targets.
April 26, 2018 -About one third of cancer cases are estimated to be linked to dietary and other modifiable risk factors, especially for obesity-related cancers such as breast, colorectal, ovarian, endometrial, kidney, gallbladder, esophageal, and pancreatic cancers. In this special theme issue of the Journal of the Academy of Nutrition and Dietetics, food and nutrition practitioners and other health professionals take an in-depth look at the relationship between nutrition, obesity, and cancer prevention, treatment, and survival and identify research gaps for future prevention research efforts.